What it is used for

Treating migraine attacks
Treating cluster headache attacks (nasal spray)

Read our guides:

Migraine

Off-label uses

Doctors sometimes prescribe a medicine for a condition it is not officially licensed for. This is called off-label use. It is legal and common when there is good evidence it helps, and your doctor should explain why they are suggesting it.

Zolmitriptan is not commonly used off-label.

How it works

Zolmitriptan acts on serotonin receptors around blood vessels and nerves in the head, narrowing the blood vessels and blocking pain signals.

Side effects

Like all medicines, Zolmitriptan can cause side effects, although not everyone gets them. Many are mild and ease after the first few weeks.

Common side effects

feeling sleepy or dizzy
tingling
tightness in the chest or throat
dry mouth
feeling sick
an unusual taste (nasal spray)

Tell your doctor or pharmacist if these bother you or do not go away.

Serious side effects

These are rare. Call 111 or contact your doctor straight away if you get:

severe chest pain or tightness that does not go away. Call 999
signs of serotonin syndrome

Call 999 if you have signs of a serious allergic reaction, such as swelling of your lips, mouth, throat or tongue, or trouble breathing.

You can report any side effect to the Yellow Card scheme, run by the medicines regulator.

Stopping and withdrawal

Important safety information

Not suitable if you have heart disease, uncontrolled high blood pressure or have had a stroke.

Questions about your medicine?

A pharmacist can answer questions about your medicines for free, without an appointment. You can also ask your GP for a medication review. Check if you can get free prescriptions.