Medicines

Pimecrolimus

Pimecrolimus is a non-steroid cream for eczema. It is often used on the face and other areas where steroid creams can thin the skin.

Type of medicine
Calcineurin inhibitor (non-steroid eczema cream)
Also known as
Elidel
Comes as
cream
How you get it
Prescription only

What it is used for

  • Mild to moderate eczema (atopic dermatitis) in adults and children aged 2 and over, when steroid creams are not suitable or have not worked

Read our guides:

Off-label uses

Doctors sometimes prescribe a medicine for a condition it is not officially licensed for. This is called off-label use. It is legal and common when there is good evidence it helps, and your doctor should explain why they are suggesting it.

  • Eczema or other inflammation around the eyes or genitals, seborrhoeic dermatitis and some other skin conditions, under a specialist

How it works

Pimecrolimus blocks calcineurin, a protein that switches on immune cells in the skin. This reduces inflammation and itching without thinning the skin.

Side effects

Like all medicines, Pimecrolimus can cause side effects, although not everyone gets them. Many are mild and ease after the first few weeks.

Common side effects

  • burning or stinging where you apply it in the first few days
  • itching
  • skin infections such as cold sores or folliculitis

Tell your doctor or pharmacist if these bother you or do not go away.

Serious side effects

These are rare. Call 111 or contact your doctor straight away if you get:

  • signs of a skin infection, such as weeping, crusting or spreading cold sores
  • swollen glands that do not go down

Call 999 if you have signs of a serious allergic reaction, such as swelling of your lips, mouth, throat or tongue, or trouble breathing.

You can report any side effect to the Yellow Card scheme, run by the medicines regulator.

Stopping and withdrawal

Important safety information

  • Avoid sunbeds and strong sunlight on treated skin.
  • Do not use it on infected skin.
  • Alcohol may cause facial flushing while you use it.

Questions about your medicine?

A pharmacist can answer questions about your medicines for free, without an appointment. You can also ask your GP for a medication review. Check if you can get free prescriptions.

Official information

Last checked 5 October 2026. Tell us if something looks wrong.

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