Medicines

Dutasteride

Dutasteride shrinks an enlarged prostate. It eases urinary symptoms and lowers the chance of needing surgery.

Type of medicine
5-alpha reductase inhibitor
Also known as
Avodart, Combodart (with tamsulosin)
Comes as
capsules
How you get it
Prescription only

What it is used for

  • Moderate to severe symptoms of an enlarged prostate (benign prostatic hyperplasia)

Read our guides:

Off-label uses

Doctors sometimes prescribe a medicine for a condition it is not officially licensed for. This is called off-label use. It is legal and common when there is good evidence it helps, and your doctor should explain why they are suggesting it.

  • Male pattern hair loss, under a specialist

How it works

Dutasteride blocks the enzymes that turn testosterone into dihydrotestosterone (DHT), a hormone that makes the prostate grow. Lower DHT slowly shrinks the prostate over 3 to 6 months.

Side effects

Like all medicines, Dutasteride can cause side effects, although not everyone gets them. Many are mild and ease after the first few weeks.

Common side effects

  • erection problems
  • lower sex drive
  • problems with ejaculation
  • breast tenderness or swelling

Tell your doctor or pharmacist if these bother you or do not go away.

Serious side effects

These are rare. Call 111 or contact your doctor straight away if you get:

  • breast lumps, pain or nipple discharge
  • low mood or thoughts of harming yourself

Call 999 if you have signs of a serious allergic reaction, such as swelling of your lips, mouth, throat or tongue, or trouble breathing.

You can report any side effect to the Yellow Card scheme, run by the medicines regulator.

Stopping and withdrawal

Important safety information

  • Women who are or may become pregnant should not handle leaking capsules, as it can harm a male baby.
  • It lowers PSA blood test results. Make sure anyone testing your PSA knows you take it.
  • Do not give blood during treatment and for 6 months after.

Questions about your medicine?

A pharmacist can answer questions about your medicines for free, without an appointment. You can also ask your GP for a medication review. Check if you can get free prescriptions.

Official information

Last checked 5 October 2026. Tell us if something looks wrong.

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