What it is used for

Helping to prevent relapse in alcohol dependence, alongside support and counselling

Read our guides:

Alcohol dependence

Off-label uses

Doctors sometimes prescribe a medicine for a condition it is not officially licensed for. This is called off-label use. It is legal and common when there is good evidence it helps, and your doctor should explain why they are suggesting it.

Disulfiram is not commonly used off-label.

How it works

Disulfiram blocks an enzyme the body uses to break down alcohol. If you drink, a substance called acetaldehyde builds up, causing flushing, a pounding heart, feeling sick, headache and breathing difficulty. Knowing this will happen helps many people avoid drinking.

Side effects

Like all medicines, Disulfiram can cause side effects, although not everyone gets them. Many are mild and ease after the first few weeks.

Common side effects

feeling sleepy or tired
bad breath or an unusual taste
feeling sick
reduced sex drive

Tell your doctor or pharmacist if these bother you or do not go away.

Serious side effects

These are rare. Call 111 or contact your doctor straight away if you get:

yellowing of the skin or eyes, dark pee or pale poo
numbness, tingling or weakness in your hands or feet
changes in your mood or behaviour

Call 999 if you have signs of a serious allergic reaction, such as swelling of your lips, mouth, throat or tongue, or trouble breathing.

You can report any side effect to the Yellow Card scheme, run by the medicines regulator.

Stopping and withdrawal

Important safety information

Do not take it until at least 24 hours after your last drink.
Avoid all alcohol, including in food, mouthwash, some medicines and toiletries.
Drinking a lot of alcohol while taking it can be dangerous.
Carry a card saying you take disulfiram.

Questions about your medicine?

A pharmacist can answer questions about your medicines for free, without an appointment. You can also ask your GP for a medication review. Check if you can get free prescriptions.