What it is used for

Type 2 diabetes
Heart failure
Chronic kidney disease

Read our guides:

Off-label uses

Doctors sometimes prescribe a medicine for a condition it is not officially licensed for. This is called off-label use. It is legal and common when there is good evidence it helps, and your doctor should explain why they are suggesting it.

Dapagliflozin is not commonly used off-label.

How it works

Dapagliflozin blocks a protein in the kidneys called SGLT2, which normally reabsorbs sugar back into the blood. Instead, extra sugar and some salt and water are passed out in your pee. This lowers blood sugar, eases strain on the heart and slows kidney damage.

Side effects

Like all medicines, Dapagliflozin can cause side effects, although not everyone gets them. Many are mild and ease after the first few weeks.

Common side effects

thrush or other genital infections
urine infections
needing to pee more
feeling thirsty
back pain
feeling dizzy

Tell your doctor or pharmacist if these bother you or do not go away.

Serious side effects

These are rare. Call 111 or contact your doctor straight away if you get:

feeling sick or being sick, stomach pain, fast breathing, sleepiness or a sweet smell on your breath, which can be signs of diabetic ketoacidosis
pain, tenderness or swelling of the genitals or the area between the genitals and back passage, with a high temperature
signs of dehydration, such as dizziness and very dark pee

Call 999 if you have signs of a serious allergic reaction, such as swelling of your lips, mouth, throat or tongue, or trouble breathing.

You can report any side effect to the Yellow Card scheme, run by the medicines regulator.

Stopping and withdrawal

Important safety information

Stop taking it and get advice if you are unwell and cannot eat or drink, or before major surgery (sick day rules).
Drink plenty of fluids.
Keep your genital area clean to lower the risk of infections.

Questions about your medicine?

A pharmacist can answer questions about your medicines for free, without an appointment. You can also ask your GP for a medication review. Check if you can get free prescriptions.