Medicines
Brimonidine
Brimonidine eye drops lower pressure in the eye in glaucoma. A gel version reduces facial redness in rosacea.
- Type of medicine
- Alpha agonist eye drops and skin gel
- Also known as
- Alphagan, Combigan (with timolol), Simbrinza (with brinzolamide), Mirvaso (gel)
- Comes as
- eye drops, gel
- How you get it
- Prescription only
What it is used for
- Open-angle glaucoma and high pressure in the eye (eye drops)
- Facial redness caused by rosacea (gel)
Read our guides:
Off-label uses
Doctors sometimes prescribe a medicine for a condition it is not officially licensed for. This is called off-label use. It is legal and common when there is good evidence it helps, and your doctor should explain why they are suggesting it.
Brimonidine is not commonly used off-label.
How it works
In the eye, brimonidine reduces the amount of fluid made inside the eye and helps it drain away, which lowers the pressure. On the skin, it narrows small blood vessels, which reduces redness.
Side effects
Like all medicines, Brimonidine can cause side effects, although not everyone gets them. Many are mild and ease after the first few weeks.
Common side effects
- red
- itchy or stinging eyes
- dry mouth
- tiredness or drowsiness
- headache
- flushing or burning skin (gel)
Tell your doctor or pharmacist if these bother you or do not go away.
Serious side effects
These are rare. Call 111 or contact your doctor straight away if you get:
- swollen, red, very itchy eyes or eyelids, which can be an allergic reaction
- feeling faint, or a very slow heartbeat
Call 999 if you have signs of a serious allergic reaction, such as swelling of your lips, mouth, throat or tongue, or trouble breathing.
You can report any side effect to the Yellow Card scheme, run by the medicines regulator.
Stopping and withdrawal
Important safety information
- The eye drops are not suitable for children under 2.
- It can make you drowsy. Do not drive if affected.
Questions about your medicine?
A pharmacist can answer questions about your medicines for free, without an appointment. You can also ask your GP for a medication review. Check if you can get free prescriptions.
Official information
Last checked 5 October 2026. Tell us if something looks wrong.
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