Medicines

Adapalene

Adapalene is a gel or cream for acne. It unblocks pores and helps stop new spots forming.

Type of medicine
Retinoid acne treatment (applied to the skin)
Also known as
Differin, Epiduo (with benzoyl peroxide)
Comes as
gel, cream
How you get it
Prescription only

What it is used for

  • Mild to moderate acne on the face, chest or back

Read our guides:

Off-label uses

Doctors sometimes prescribe a medicine for a condition it is not officially licensed for. This is called off-label use. It is legal and common when there is good evidence it helps, and your doctor should explain why they are suggesting it.

  • Some other skin conditions with blocked pores, such as keratosis pilaris, under a dermatologist

How it works

Adapalene is a retinoid, a medicine related to vitamin A. It makes skin cells turn over more quickly, which stops them blocking pores. It also reduces inflammation, so spots are less red and swollen.

Side effects

Like all medicines, Adapalene can cause side effects, although not everyone gets them. Many are mild and ease after the first few weeks.

Common side effects

  • dry
  • flaky or peeling skin
  • redness
  • stinging or burning when you apply it
  • skin being more sensitive to sunlight

Tell your doctor or pharmacist if these bother you or do not go away.

Serious side effects

These are rare. Call 111 or contact your doctor straight away if you get:

  • severe redness, swelling, blistering or crusting of the skin

Call 999 if you have signs of a serious allergic reaction, such as swelling of your lips, mouth, throat or tongue, or trouble breathing.

You can report any side effect to the Yellow Card scheme, run by the medicines regulator.

Stopping and withdrawal

Important safety information

  • Do not use it if you are pregnant or trying to get pregnant.
  • Acne often looks a little worse in the first few weeks before it improves. It can take up to 12 weeks to see the full benefit.
  • Use sunscreen and avoid sunbeds.

Questions about your medicine?

A pharmacist can answer questions about your medicines for free, without an appointment. You can also ask your GP for a medication review. Check if you can get free prescriptions.

Official information

Last checked 5 October 2026. Tell us if something looks wrong.

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