Acamprosate

What it is used for

• Helping to keep you alcohol-free after you have stopped drinking (alcohol dependence), usually for up to 6 months or longer

Read our guides:

• Alcohol dependence

Off-label uses

Doctors sometimes prescribe a medicine for a condition it is not officially licensed for. This is called off-label use. It is legal and common when there is good evidence it helps, and your doctor should explain why they are suggesting it.

Acamprosate is not commonly used off-label.

How it works

Long-term heavy drinking changes the balance of chemical messengers in the brain, especially glutamate and GABA. Acamprosate is thought to help restore this balance, which can reduce cravings and the urge to drink after you have stopped.

Side effects

Like all medicines, Acamprosate can cause side effects, although not everyone gets them. Many are mild and ease after the first few weeks.

Common side effects

• diarrhoea
• feeling sick or being sick
• stomach pain
• itching
• rash
• changes in sex drive

Tell your doctor or pharmacist if these bother you or do not go away.

Serious side effects

These are rare. Call 111 or contact your doctor straight away if you get:

• low mood, or thoughts of harming yourself
• a severe skin rash with blisters or peeling

Call 999 if you have signs of a serious allergic reaction, such as swelling of your lips, mouth, throat or tongue, or trouble breathing.

You can report any side effect to the Yellow Card scheme, run by the medicines regulator.

Stopping and withdrawal

Important safety information

• It is usually started as soon as possible after alcohol withdrawal (detox) is complete.
• It is not suitable for people with severe kidney or liver problems.
• It works best with counselling or a support group.

Questions about your medicine?

A pharmacist can answer questions about your medicines for free, without an appointment. You can also ask your GP for a medication review. Check if you can get free prescriptions.